The freeway enters Tennessee directly in the Chattanooga metropolitan area, where it intersects with Interstate 24. Exiting Chattanooga to the northeast, Interstate 75 does not meet any other highways until it is multiplexed with Interstate 40 and heads eastbound. Together, they enter the outskirts of Knoxville, where Interstate 75 multiplexes itself with a different road, this time Interstate 640, but only for a short time. When the two meet Interstate 275, Interstate 75 becomes its own freeway and heads north towards the Kentucky border.